Biomolecules Folding and Disease
The course Laboratory of Bioinformatics 1 (66563) includes in the second semester a 60-hours module given by
The course director is Prof. Rita Casadio.
The module is running from March 12 to April 17, 2019 in the Laboratory of Bioinformatics at the ground floor of Via San Giacomo 9/2 (back entrance).
This page will include all the slides and materials of the lectures.
|Introduction and Basic Concepts||12 March, 2019.|
|Protein and RNA Structure Alignment||14 and 15 March, 2019.|
|Multiple Alignments||19 and 21 March, 2019.|
|Hidden Markov Models||22 March, 2019.|
|HMM Alignments||26 March, 2019.|
|HMMER||28 March, 2019.|
|Introduction to the Project||29 March and 1 April, 2019.|
|Project Implementation||2-11 April, 2019.|
|Protein Structure Prediction||12 April, 2019.|
|Protein Structure Analysis||15 April, 2019.|
|Analysis and Prediction of Protein Complex||16 April, 2019.|
|Predicting the Effect of Protein Variants||17 April, 2019.|
|This is a theoretical and hands-on module which requires the use of PC. Students need to use their own laptop. Practical session of the course will be performed on a Linux OS.|
Structural Bioinformatics II Edition:
Structural Comparison and Alignment.
by Marti-Renom et al.
A Comprehensive Benchmark Study of Multiple Sequence Alignment Methods: Current Challenges and
Future Perspectives. PLOS ONE, 2011.
by Thompson et al.
The Pfam protein families database in 2019.
Nucleic Acids Research, 2019.
by El-Gebali et al.
Assignment of protein sequences to existing domain and family classification systems: Pfam and the PDB.
by Xu and Dunbrack.