Biomolecules Folding and Disease

The course Laboratory of Bioinformatics 1 (66563) includes in the second semester a 60-hour module given by Emidio Capriotti. The course director is Prof. Rita Casadio. The module was running from March 9 to April 30, 2021 and the lectures will be given online through the URL https://bit.do/unibo-lb1. This page will include all the slides and materials of the course.

• Materials
  

  Course Schedule
  Introduction and Basic Concepts	9 March, 2021.
  Protein and RNA Structure Alignment	11 and 12 March, 2021.
  Multiple Alignments	16, 18 and 19 March, 2021.
  Probabilistic Models for Biological Sequences	23 March, 2021.
  Hidden Markov Models	25 March, 2021.
  HMM for Seqnence Alignment	26 March, 2021.
  HMMER	30 March, 2021.
  Introduction to the Project	8, 13 and 15 April, 2021.
  Project Implementation	16-27 April, 2021.
  Predicting the effect of protein variants	29 and 30 April, 2021.
  Hands-On Programming Sessions




• Requirements
  

This is a theoretical and hands-on module which requires the use of PC. Students need to use their own laptop. Practical session of the course will be performed on a Linux OS.




• References
  

Marti-Renom et al. Structural Bioinformatics II Edition: Structural Comparison and Alignment.

Thompson et al. A Comprehensive Benchmark Study of Multiple Sequence Alignment Methods: Current Challenges and Future Perspectives. PLOS ONE, 2011.

El-Gebali et al. The Pfam protein families database in 2019. Nucleic Acids Research, 2019.

Loewenstein et al. Protein function annotation by homology-based inference. Genome Biology, 2009.

Xu and Dunbrack. Assignment of protein sequences to existing domain and family classification systems: Pfam and the PDB. Bioinformatics, 2012.




• Previous Editions
  

March 2020:	The previous edition of the Module 2 of the Laboratory of Bioinformatics 1 course (10 March - 30 April, 2020) was successfully completed (more information are available here).
March 2019:	The previous edition of the Module 2 of the Laboratory of Bioinformatics 1 course (12 March - 17 April, 2019) was successfully completed (more information are available here).
March 2018:	The previous edition of the Module 2 of the Laboratory of Bioinformatics 1 course (13 March - 3 May, 2018) was successfully completed (more information are available here).
March 2017:	The previous edition of the Module 2 of the Laboratory of Bioinformatics 1 course (13 March - 4 May, 2017) was successfully completed (more information are available here).